Biotin

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Biotin B-Complex Thickening Conditioner, 14 oz. From Avalon

Reg. Price: $9.95

Your Price: $6.60

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Biotin High Potency, 60 Vcaps, 5 mg, From Country Life

Reg. Price: $14.99

Your Price: $7.33

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Alpha Lipoic Sustain 300 with Biotin, 60 Tablets, 300mg, From Jarrow

Reg. Price: $24.95

Your Price: $17.47

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Natural Biotin Shampoo, 16 oz. From Jason Natural

Reg. Price: $9.95

Your Price: $6.30

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Super Alpha-Lipoic Acid With Biotin, 60 Capsules, 250 mg, From Life Extension

Reg. Price: $36.99

Your Price: $27.75

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Biotin Shampoo, 16 fl oz 473 ml, From Mill Creek

Reg. Price: $7.49

Your Price: $5.40

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Deep Conditioning Biotin Gel, 4 fl oz, From Mill Creek

Reg. Price: $6.99

Your Price: $5.40

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Biotin 5000 Biotion Formula 5000 mcg, 60 Capsules, From Nutricology

Reg. Price: $15.50

Your Price: $8.59

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Biotin Promotes Healthy Hair & Nails, 90 Tablets, 300 mcg, From Natural Factors

Reg. Price: $6.95

Your Price: $4.17

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Biotin Strengthening Conditioner, 18 oz, From Nature's Gate

Reg. Price: $7.29

Your Price: $4.68

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Biotin Strengthening Shampoo, 18 oz, From Nature's Gate

Reg. Price: $7.29

Your Price: $4.68

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Biotin 2500 Mcg, 100 Capsules, From Nature's Life

Reg. Price: $16.99

Your Price: $8.98

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Biotin, 100 Capsules, 1000 mcg, From NOW

Reg. Price: $6.99

Your Price: $3.49

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Biotin, 120 Vcaps, 5,000mcg, From NOW

Reg. Price: $17.99

Your Price: $8.99

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Eggwhite Powder with Biotin, 1 lb, From NOW

Reg. Price: $21.99

Your Price: $14.99

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Biotin 1000 Mcg, 100 Lozenges, From Nature’s Way

Reg. Price: $10.49

Your Price: $5.25

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Purvana - Hair Skin and Nails, 2500mcg Biotin Per Gel, 30 Softgels

Reg. Price: $19.99

Your Price: $11.69

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Biotin, Yeast Free, 100 Capsules, From Twinlab

Reg. Price: $11.01

Your Price: $5.40

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Men's Stock Ginseng Biotin Hair Gel, 6 oz., From Aubrey

Reg. Price: $9.95

Your Price: $7.61

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Men's Stock Ginseng Biotin Hair Repair, 8 oz, From Aubrey

Reg. Price: $15.98

Your Price: $12.22

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Biotin, 5 mg, 100 Capsules, From Jarrow Formulas

Reg. Price: $15.95

Your Price: $8.00

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Biotin, 5,000 mcg, 60 Veggie Caps, From LifeTime Vitamins

Reg. Price: $14.25

Your Price: $9.06

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Biotin, 1000 mcg, 100 Tablets, From Natrol

Reg. Price: $10.49

Your Price: $5.75

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Biotin, Yeast Free, 100 Capsules, From Twinlab

Reg. Price: $11.01

Your Price: $5.40

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Biotin B-Complex Thickening Shampoo, 14 oz. From Avalon

Reg. Price: $9.95

Your Price: $6.60

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Biotin, 1000 mcg, 250 Tablets, From Carlson Laboratories

Reg. Price: $19.90

Your Price: $9.95

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Biotin Forte, 3 mg with Zinc, 60 Tablets, From Enzymatic Therapy

Reg. Price: $12.50

Your Price: $8.50

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Natural Biotin Conditioner, 16 oz. From Jason Natural

Reg. Price: $9.95

Your Price: $6.30

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Biotin Powder 1%, 30 g, From Life Extension

Reg. Price: $12.99

Your Price: $9.50

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Biotin and Folic Acid S/R, 30 Tablets, From Nature's Plus

Reg. Price: $11.99

Your Price: $9.81

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Biotin, 120 Tablets, 5 mg, From Source Naturals

Reg. Price: $26.99

Your Price: $12.92

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Biotin 600mcg 100+100t, From Source Naturals

Reg. Price: $7.25

Your Price: $6.58

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Biotin, 500 mcg, 60 Capsules, From Thompson Nutritional

Reg. Price: $12.99

Your Price: $6.40

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Supreme Vital Hair, 90 Tablets, From LifeTime Vitamins

Reg. Price: $20.99

Your Price: $13.62

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Biotin, 1000 mcg, 100 Tablets, From Country Life

Reg. Price: $9.25

Your Price: $4.56

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High Biotin, 5 mg, 120 Veggie Caps, From Country Life

Reg. Price: $25.49

Your Price: $8.89

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Biotin, 600 mcg, 100 Capsules, From Life Extension

Reg. Price: $7.50

Your Price: $5.35

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Biotin, High , 800 mcg, 90 Tablets, From Thompson Nutritional

Reg. Price: $4.29

Your Price: $2.20

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Yeast Fighters, 75 Capsules, From Twinlab

Reg. Price: $15.99

Your Price: $7.83

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Biotin 500 mcg 100 Tablets, Country Life

Reg. Price: $5.94

Your Price: $5.66

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Biotin 1000 mcg, 60 Tablets, FoodScience Of Vermont

Reg. Price: $6.16

Your Price: $5.40

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Biotin 10,000 mcg Maximum Strength, 100 Tablets, Natrol

Reg. Price: $8.70

Your Price: $8.50

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Biotin 1000 mcg Fast Dissolve, Cherry, 90 Tablets, Natrol

Reg. Price: $8.70

Your Price: $6.50

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Biotin Vitamin H 1000mcg, 60 Capsules, Olympian Labs

Reg. Price: $9.24

Your Price: $8.95

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Biotin

Biotin

Biotin, also known as vitamin H or B7 and C10H16N2O3S (Biotin; Coenzyme R, Biopeiderm), is a water-soluble B-complex vitamin which is composed of an ureido (tetrahydroimidizalone) ring fused with a tetrahydrothiophene ring. A valeric acid substituent is attached to one of the carbon atoms of the tetrahydrothiophene ring. Biotin is important in the catalysis of essential metabolic reactions to synthesize fatty acids, in gluconeogenesis, and to metabolize leucine.

Biotin is used in cell growth, the production of fatty acids, metabolism of fats, and amino acids. It plays a role in the Krebs Cycle, which is the process in which energy is released from food. Biotin not only assists in various metabolic chemical conversions, but also helps with the transfer of carbon dioxide. Biotin is also helpful in maintaining a steady blood sugar level. Biotin is often recommended for strengthening hair and nails. Consequently, it is found in many cosmetic and health products for the hair and skin.

Deficiency is extremely rare, save in cases where people have ingested large amounts of raw egg white over long periods of time, as intestinal bacteria generally produce in excess of the body's daily requirement. For that reason, statutory agencies in many countries (e.g., the Australian Department of Health and Aging) do not prescribe a recommended daily intake.

Biotin supplements are often recommended as a natural product to counteract the problem of hair loss in both children and adults. There are, however, no studies that show any benefit in any case where the subject is not actually biotin deficient. The signs and symptoms of biotin deficiency include hair loss which progresses in severity to include loss of eye lashes and eye brows in severely deficient subjects. Some shampoos are available that contain biotin, but it is doubtful whether they would have any useful effect, as biotin is not absorbed well through the skin.

Cradle cap (seborrheic dermatitis)
Children with a rare inherited metabolic disorder called phenylketonuria (PKU; in which one is unable to break down the amino acid phenylalanine) often develop skin conditions such as eczema and seborrheic dermatitis in areas of the body other than the scalp. The scaly skin changes that occur in people with PKU may be related to poor ability to use biotin. Increasing dietary biotin in the diet has been known to improve seborrheic dermatitis in these cases.


Diabetes
People with type 2 diabetes often have low levels of biotin. Biotin may be involved in the synthesis and release of insulin. Preliminary studies in both animals and people suggest that biotin may help improve blood sugar control in those with diabetes, particularly type 2 diabetes. [citation needed]


Biotin deficiency
Biotin deficiency is a rare nutritional disorder caused by a deficiency of biotin. Biotin deficiency can have a very serious, even fatal, outcome if it is allowed to progress without treatment. Signs and symptoms of biotin deficiency can develop in persons of any age, race, or gender. Biotin deficiency rarely occurs in healthy individuals, since the daily requirements of biotin are low, many foods contain adequate amounts, intestinal bacteria synthesize small amounts, and the body effectively scavenges and recycles biotin from bodily waste. However, deficiency can be caused by excessive consumption of raw egg-whites over a long period (months to years). Egg-whites contain high levels of avidin, a protein that binds biotin stongly. Once a biotin-avidin complex forms, the bond is essentially irreversible. The biotin-avidin complex is not broken down nor liberated during digestion, and the biotin-avidin complex is lost in the feces. Once cooked, the egg-white avidin becomes denatured and entirely non-toxic.


Initial symptoms of biotin deficiency include:
  • Hiar Loss
  • Dry skin
  • Seborrheic dermatitis
  • Fungal infections
  • Rashes including erythematous periorofacial macular rash
  • Fine and brittle hair
  • Hair loss or total alopecia


  • If left untreated, neurological symptoms can develop, including:
  • Mild depression, which may progress to profound lassitude and, eventually, to somnolence
  • Changes in mental status
  • Generalized muscular pains (myalgias)
  • Hyperesthesias and paresthesias


  • The treatment for biotin deficiency is to simply start taking some biotin supplements.

    Biochemistry

    Biotin is a cofactor responsible for carbon dioxide transfer in several carboxylase enzymes:
  • Acetyl-CoA carboxylase
  • Methylcrotonyl-CoA carboxylase
  • Propionyl-CoA carboxylase
  • Pyruvate carboxylase


  • The attachment of biotin to various proteins, called biotinylation, is an important process in DNA transcription and replication.

    Biotin binds very tightly to the tetrameric protein streptavidin, with a dissociation constant Kd in the order of 10-14 mol/L. This is often used in different biotechological applications. Until 2005, very harsh conditions were required to break the biotin-streptavidin bond (Holmberg et al, 2005).

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    Biotin