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Guggulsterones
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List ViewGuggulbolic, 90 Capsules, From SyntraxCost Per Serving : $0.18 |
Thyroid T-3, Radical Metabolic Booster, 180 Capsules, Thyroid T 3, From Absolute NutritionCost Per Serving : $0.11 |
Ultra Guggulow, Helps Maintain Cholesterol, 90 Tablets, 1000mg, From Doctor's BeCost Per Serving : $0.15 |
Ripped Juice Extreme, Fat Incinerator, 80 Capsules, From BetancourtCost Per Serving : $0.30 |
Guggul Complex, 90 Capsules, From DymatizeCost Per Serving : $0.13 |
Guggul Extract, 90 Capsules, 750mg, From NOWCost Per Serving : $0.12 |
Herbal Actives Gugulipid 750 Mg, 60 Capsules, From Nature's PlusCost Per Serving : $0.41 |
T3, Fat Burning, 90 Capsules, From SANCost Per Serving : $0.11 |
Tight RTD, 12 Cans, From SANCost Per Serving : $2.08 |
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Grid View Grid View List View List ViewGuggulsterones
What is Guggul?
Guggul, also called guggulipid, is an ethyl acetate extract of the gum resin of the guggul tree Commiphora mukul, a small bushy tree found in India, Bangladesh, and Pakistan. This yellowish gum resin has been used for more than 2000 years in Ayurvedic to treat a variety of ailments, and many active constituents have been identified. It has been studied in the treatment of many conditions, including hyperlipidemia, obesity, and arthritis.
What application does Guggul have?
Although the majority of studies on guggulipid have been on its cholesterol lowering ability, it has also been identified as a weight loss agent. It activates lipolytic enzymes and increases T3 levels, presumably due to increased conversion of T4 to T3 in the liver, although it may also stimulate the thyroid directly. Quite a few studies have been done on both humans and animals accessing guggul's ability to stimulate fat loss. Animal studies have shown a positive effect, and human studies have either shown a benefit or have been equivocal. Unfortunately, many of these studies were inadequately controlled. A study that controlled for BMI, concurrent drug use, diet, and exercise found that people who took guggul lost 1.92 kg after 15 days compared with .32 kg in the control group.
How does Guggul work?
As stated, orally administered guggulipid increases T3 (tryiidothyronine) levels in animal models. T3 is the conversion product of T4, which is produced by the thyroid gland. Thyroid hormone levels are intricately involved in metabolic homeostasis. Increased thyroid levels cause more fat to be burned and decreased levels increase the likelihood of fat being stored. When one normally goes on a diet, the body responds by decreasing T3 levels and thus decreasing metabolic rate. But if T3 levels are increased, diets are much more effective at causing fat loss. It has not been established how guggulipid increases T3 levels, but the prevailing theory is that it is by decreasing lipid peroxidation.
What Benefits does Guggul have?
What are the side effects?
The studies do not report serious side effects, although some users experienced gastrointestinal discomfort which did not necessitate discontinuation. High doses have been used without the incidence of ill effects. Guggul may compete with some cholesterol reducing medications, so if you are on such medications you should consult a doctor before taking guggul. Likewise, you should consult a doctor if you have a thyroid disorder.
The primary side effect that the athlete should be worried about is the possibility of muscle catabolism. Increased thyroid levels may also increase mitochondrial uncoupling of muscle tissue and decrease insulin secretion and NO Formula production. Although fat loss will still be the primary effect, a portion of the weight lost may be from muscle. Fortunately, you can avoid or at least highly limit the amount of catabolism caused by increased thyroid levels by increasing your testosterone levels, because testosterone blocks the pathway through which thyroid-induced protein uncoupling occurs.
What form of Guggul is best?
As guggul has various constituents, isolating the desirable ones may increase its effectiveness while reducing unwanted side effects. On the other hand, in the case of many of the constituents of guggul, the activity has not been adequately studied - especially for fat loss purposes - so it may be unwise to leave these out.
How should I take Guggul?
Guggul will be most helpful when thyroid hormone levels are suppressed, such as when you are in a caloric deficit. The effective dose is 50-100 mg of total guggulsterones daily, or 1 mg/kg of body weight, spread out over three doses. With synthetic guggulsterones, a lower amount should achieve the same effect. Cycling is probably not necessary - increased T3 levels can cause natural thyroid hormone suppression, but this effect quickly disappears after discontinuation even with long term use.
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Guggulsterones
Guggulsterones