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Neptune Krill Oil (NKO)
Neptune Krill Oil (NKO) is the "new kid on the block” among omega-3 oil products. Yet it has already gone "toe to toe” with the market standard—fish oil caps—in a published double-blind controlled study and soundly beaten the current favorite.
Neptune Krill Oil (NKO) is about to usher in a new era in effective omega-3 (EPA/DHA) supplementation. Derived from Antarctic krill, hardy shrimp-like organisms, NKO has many beneficial differences from fish oil supplements.
The EPA/DHA in fish oils are in triglyceride form, while NKO's EPA/DHA are present as phospholipids, primarily phosphatidyl choline.
Not only are DHA phospholipids key components of human cell membranes, especially nerve cell membranes,but they are far better absorbed than triglycerides. Indeed, the soy-derived phospholipid lecithin is often used to emulsify other lipid compounds to enhance their digestive absorption.
Neptune Krill Oil (NKO) is also amazingly stable, strongly able to resist turning rancid. In the oil stability test, NKO is able to maintain the extremely low peroxide (rancid fat) level of less than 0.05 mEq for over 50 hours at 97.8 degrees C (208 degrees F), while fish oil goes rancid within 8 hours at 80 degrees C (176 degrees F).5 This is a major point in NKO's favor, since the notorious proneness of fish oil caps to turn rancid (EPA and DHA are the most rancidity-prone of all polyunsaturated fatty acids) has always been the main drawback to their safe use.
Neptune Krill Oil (NKO)
NKO: Unique Antioxidant Profile
Neptune Krill Oil (NKO) contains a unique combination of antioxidants integrated into its phospholipids structures. Small amounts of vitamins A and E, along with the powerful carotenoid antioxidant astaxanthin, help provide the unique stability to NKO. A novel flavonoid, the first ever found outside the plant kingdom, also enhances NKO's stability.
Brunswick Laboratories of Wareham, Mass., performed a series of tests to measure NKO's antioxidant power and compare it to other nutrients. Using the standard ORAC (oxygen radical absorbance capacity) analysis, which compares the antioxidant power of a test substance to a reference standard (Trolox, a synthetic vitamin E analog), the lab found vitamins A and E have ORAC values of 1.25; lutein and fish oil, 8; CoQ10, 11; astaxanthin, 51; and lycopene, 58. NKO has an amazing ORAC value of 378!
Thus, not only is NKO superstable, but it's a superantioxidant. And since the multiple antioxidants that create NKO's super ORAC value are integral to its DHA/EPA phospholipids, it is reasonable to assume that NKO's antioxidants will increase the stability of whatever membranes they become part of.
Support Your Protective Cell Membranes
Neptune Krill Oil is the only product to boast significant healthinducing potencies from three different important nutritional categories: omega3 fatty acids, phospholipids and antioxidants. These three nutrients work together to support healthy cell membranes, joints, the heart and many other body systems. And Neptune Krill Oil eases PMS symptoms for women.
NKO Reduces Animal Skin Cancer
Ninety-six Nude Congenic mice were treated with either NKO or placebo by various routes. They were exposed to both "normal” and "high” levels of skin cancer-promoting UVB radiation. Comparing 48 NKO mice to 48 placebo mice after 20 weeks (including both high and normal UVB exposure), 16.7 percent of the NKO mice developed skin cancer, 27.1 percent developed premalignant lesions, and 56.3 percent remained normal.
Of the placebo mice, 37.5 percent developed cancer, 20.8 percent had premalignant lesions, and 41.7 percent remained normal. Looking just at the mice that received "normal” UVB exposure, 13.3 percent of the NKO mice developed cancer, 6.6 percent had premalignant lesions and 80.1 percent remained normal. Of the placebo mice, 26.7 percent developed skin cancer, 20 percent had premalignant lesions, and 53.3 percent remained normal. Clearly NKO proved effective at reducing UVB-induced skin cancer.
NKO: Clinical Trials
In 2003 the results of a clinical trial testing NKO against fish oil to manage premenstrual syndrome (PMS) and dysmenorrhea (painful menstruation) were published.
Conducted at medical centers in Quebec, Canada, 36 women were given NKO and 34 received fish oil over a 90-day trial in a double-blind study. Questionnaires assessing 10 different symptoms on a 0-to-10 scale (0 = no problem, 10 = unbearable) were filled out at day 0, day 45 and day 90 of the trial.
Two grams of NKO or fish oil were given daily the first month, then two grams daily for eight days before and two days after the onset of menstruation during the second and third months.
By day 45, the NKO women had highly statistically significant reductions in symptom severity for all 10 symptoms: breast tenderness, feeling overwhelmed, stress, irritability, depression, joint pain, weight gain, abdominal pain, swelling and bloating. The fish oil group had statistically significant reductions only in weight gain and abdominal swelling at day 45.
By day 90 the NKO group had achieved further reductions in severity score for all 10 symptoms, while the fish oil group had statistical improvements only in weight gain, abdominal pain and swelling. The NKO final scores for those three parameters were lower than each of the corresponding fish oil scores.
The study also measured analgesic (pain killer) use of the 70 women. At baseline, women in both groups took an average of 1.2 grams ibuprofen or 2.5 grams acetaminophen daily during PMS/menstruation.
By day 45, the NKO group took only 0.9 grams ibuprofen or 1.5 grams acetaminophen. The fish oil group took on average 0.9 grams ibuprofen or 1.65 grams acetaminophen by day 45.
By day 90, the NKO group took 0.6 grams ibuprofen (50 percent drop from baseline) or 1.0 grams acetaminophen (60 percent drop). The fish oil group had lowered to 0.8 grams ibuprofen (33 percent drop) or 1.48 grams acetaminophen (41 percent drop) by day 90. Sixty-four percent of the fish oil group complained of unpleasant fishy taste/odor regurgitation, while none of the NKO group had that problem.
An added plus to the study findings was that " …the NKO subjects reported an increase of alertness, energy, and well-being.”
Acute Toxicity Study
An acute toxicity study with NKO was conducted for two months. Twenty-two men and women, ages 25 to 53, took two grams NKO three times daily. An exhaustive series of laboratory tests measuring more than 20 parameters was analyzed by an independent laboratory. No noticeable physical or laboratory adverse events occurred. There were significant reductions in total blood cholesterol, triglycerides and LDL cholesterol, with a significant increase in HDL ("good”) cholesterol.
Study subjects reported such benefits as increased ability to concentrate, decreased seasonal allergy symptoms, increased skin hydration, improved hair texture, decreased joint discomfort and reduced PMS symptoms.
NKO vs. Hyperlipidemia
One hundred twenty patients with mild to severe hyperlipidemia (high blood cholesterol/triglycerides) were studied in four groups of 30 for three months in a randomized, controlled study.
Thirty received 1.5 grams NKO once daily, 30 received 3 grams NKO once daily, 30 were given 3 grams fish oil once daily, and 30 received 1.5 grams placebo once daily. At baseline and 90 days later cholesterol, triglycerides, LDL and HDL levels, and cholesterol/HDL ratios were measured. At the end of 90 days, all parameters had worsened in the placebo group.
Among the fish oil group, total cholesterol had dropped 1.8 percent, triglycerides dropped 4.4 percent, LDL dropped 2.5 percent, HDL increased 4.7 percent, and the cholesterol/HDL ratio improved 5.8 percent.
Among the 1.5 gram NKO group, total cholesterol dropped 13.6 percent, triglycerides fell 11.5 percent, LDL dropped 33.9 percent, and HDL rose 43.5 percent. The cholesterol/HDL ratio improved 13.4 percent.
Among the 3 gram NKO group, total cholesterol dropped 17.9 percent, triglycerides fell 27.4 percent, LDL went down 22.8 percent, and HDL rose 36.4 percent. The cholesterol/HDL ratio improved 19.3 percent. Thus, even the 1.5 gram NKO dose was dramatically more effective in improving blood lipid profiles than the 3 gram/day fish oil dose.
NKO: Final Comments
NKO has been shown to be a safe and more effective EPA/DHA source compared to fish oil, even though it has a lower percentage of EPA/DHA (24 percent, compared to 30 to 50 percent for most fish oils).
The combination of phospholipid-enhanced absorption and superantioxidant protection of NKO's omega-3 oils doubtless makes up for that difference.
Because NKO is derived from a seafood, those known to be seafood-allergic should use NKO only with caution, or after suitable allergy testing. Those taking anticoagulant medication, or who suffer from extreme bleeding conditions, should use NKO only with medical supervision.
It is suggested that 1 to 2 grams (2 to 4 capsules) NKO be taken daily for one to two months, then a maintenance dose of 0.5 to 1 gram (1 to 2 capsules) be taken daily, dose depending on health issues and body size.
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